Tumor organoids are 3D cultures of cancer cells. They can be derived from the tumor of each
individual patient, thereby providing an attractive ex vivo assay to tailor treatment. Using …

Background Genome-wide association studies (GWAS) have revealed many susceptibility
loci for complex genetic diseases. For most loci, the causal genes have not been identified. …

Advances in molecular tumour diagnostics and the number of targeted therapies increase
rapidly. Molecular tumour boards (MTBs) are designated to interpret these data and provide …

3013 Background: In the next few years numerous drugs will be approved for defined genomic
targets, most of these in a tumor agnostic manner. Identifying patients who can benefit …

Background In this study, our aim was to identify molecular aberrations predictive for
response to everolimus, an mTOR inhibitor, regardless of tumor type. Methods To generate …

TPS4154 Background: Esophageal cancer is the 6th leading cause of mortality worldwide,
with an overall 5-year survival rate of 10%. This is in part due to more than 50% of patients …

Het in kaart brengen van genetische veranderingen in het kankergenoom door middel van
DNA-‘sequencing’-technieken heeft het inzicht in de tumorgenese en tumorprogressie de …

Characterization of the molecular environment of the protein tyrosine phosphatase PTP-BL
Characterization of the molecular environment of the protein tyrosine phosphatase PTP-BL Page …

TPS3149 Background: With the emergence of large-scale genetic tumor profiling and the
increasing availability of approved targeted therapies, precision medicine has become crucial …

5014 Background: Recent genome analysis efforts have shown that genomic alterations
obtained from primary and metastatic prostate cancer (mPCa) vary widely, stressing the need to …