Polycomb Group proteins are important epigenetic regulators of gene expression. Epigenetic
control by polycomb Group proteins involves intrinsic as well as associated enzymatic …

Most human coronaviruses cause mild upper respiratory tract disease but may be associated
with more severe pulmonary disease in immunocompromised individuals 1 . However, …

Stromal interaction molecule 1 (STIM1) is a transmembrane protein that is essential for store-operated
Ca 2+ entry, a process of extracellular Ca 2+ influx in response to the depletion of …

Dendritic spines are the major sites of excitatory synaptic input, and their morphological
changes have been linked to learning and memory processes. Here, we report that growing …

Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene
silencing during differentiation and development. PRC1 recruitment is generally attributed …

In neurons, the distinct molecular composition of axons and dendrites is established through
polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such …

Recent evidence indicates there is a role for small membrane vesicles, including exosomes,
as vehicles for intercellular communication. Exosomes secreted by most cell types can …

Gene expression profiling has identified numerous processes altered in aging, but how these
changes arise is largely unknown. Here we combined nascent RNA sequencing and RNA …

DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the
assembly of several proteins on DNA ends. Although biochemical studies have elucidated …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors have …