CD8 T cell activation after intravenous administration of CD3× CD19 bispecific antibody in patients with non-Hodgkin lymphoma

GC De Gast, IA Haagen, AA van Houten… - Cancer Immunology …, 1995 - Springer
A bispecific antibody directed to T and B cells (CD3×CD19 bsAb) was daily infused
intravenously in escalating doses from 10 μg up to 5 mg in three patients with chemotherapy-…

Prevention of primary transfusion‐associated cytomegalovirus infection in bone marrow transplant recipients by the removal of white cells from blood components with …

HC Prooijen, JJ Visser, WR Oostendorp… - British journal of …, 1994 - Wiley Online Library
A prospective study was carried out to determine whether use of cytomegalovirus (CMV)
unscreened red blood cells and platelet concentrates, white blood cell (WBC) depleted with high…

[HTML][HTML] Allogeneic bone marrow transplantation with a fixed low number of T cells in the marrow graft

LF Verdonck, AW Dekker, GC de Gast, ML van Kempen… - Blood, 1994 - Elsevier
Despite prophylaxis with immunosuppressive drugs, severe acute graft-versus-host disease
(GVHD) remains a major cause of morbidity and mortality in patients transplanted with …

Detection improvement of cytomegalovirus antigen in human peripheral blood using monoclonal antibodies and automated reading of cell preparations

GJ Boland, WE Mesker, R Doorn… - European journal of …, 1995 - Wiley Online Library
One of the major drawbacks in cytomegalovirus (CMV)‐antigenaemia detection for
diagnosis of active CMV infection is the low number of CMV‐antigen positive cells present in …

Early detection of primary cytomegalovirus infection after heart and kidney transplantation and the influence of hyperimmune globulin prophylaxis

GJ Boland, C Ververs, RJ Hené, G Jambroes… - Transplant …, 1993 - Springer
A randomized study of prophylaxis with hyper-immune globulin (HIg) was performed in 28
cytomegalovirus (CMV)-seronegative heart and kidney recipients with CMV-seropositive …

Suppression of DNA synthesis by Con A-activated human lymphocytes: Stimulation by con A bound to non-T cells unless removed after activation.

GC De Gast, TH The, E Ponds… - Clinical and Experimental …, 1977 - ncbi.nlm.nih.gov
The capacity of human peripheral blood lymphocytes to suppress DNA synthesis of other
lymphocytes was studied in an assay consisting of two steps: firstly, activation by Con A during …

Class-specific antibody titres (ELISA) against the primary immunogen Helix pomatia haemocyanin (HPH) in man.

J Weits, GC De Gast, TH The, MT Esselink… - Clinical and …, 1978 - ncbi.nlm.nih.gov
Using the indirect ELISA technique, IgM, IgG and IgA antibody titres against the primary test
immunogen Helix pomatia haemocyanin (HPH) could be measured. All twenty-seven normal …

Immune function during ageing in man: relation between serological abnormalities and cellular immune status

HM Lokhorst, JA LINDEN… - European Journal of …, 1983 - Wiley Online Library
In a group of 176 apparently healthy aged people living at home (age range 62–86 years) the
prevalences of monoclonal immunoglobulin and of autoantibodies did not differ from those …

Prevention of primary cytomegalovirus infection in patients with hematologic malignancies by intensive white cell depletion of blood products

YCE Graan‐Hentzen, JW Gratama, GC Mudde… - …, 1989 - Wiley Online Library
The effect of white cell depletion of red cells and platelet concentrates on the transmission
of cytomegalovirus (CMV) was studied retrospectively in 150 patients treated intensively for …

Expression of restricted immunoglobulin isotypes in plasmacellular hyperplasia after allogeneic bone marrow transplantation

HJ Schuurman, RW Hendriks… - Scandinavian …, 1987 - Wiley Online Library
Plasmacellular hyperplasia in lymphoid tissue was found in 4 out of 9 patients 1‐6 months
after allogeneic bone marrow transplantation as treatment for leukaemia. In the plasma cell …