Rationale: Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor
gating: prepulse inhibition (PPI) of startle. Similar deficits in PPI are produced in rats by …

… Geyer MA: Heterogenous functions of discrete serotonergic pathways in brain, in Usdin E,
Mandell AJ (eds): New Vistas in the Biochemistry of Mental Disorders. New York, Marcel …

Studies of prepulse inhibition and habituation of startle responses elicited by intense stimuli
provide some unusual opportunities for cross-species explorations of attentional deficits …

Schizophrenic patients exhibit deficits in the prepulse inhibition of startle, an operational
measure of the sensorimotor gating deficits that are theorized to contribute to cognitive …

• Schizophrenic patients exhibit impairments in both sensorimotor gating and habituation in
a number of paradigms. Through human and animal model research, these fundamental …

Rationale: Since the mid-1970s, cross-species translational studies of prepulse inhibition (PPI)
have increased at an astounding pace as the value of this neurobiologically informative …

The most commonly cited descriptions of the behavioral characteristics of habituation come
from two papers published almost 40 years ago [Groves, PM, & Thompson, RF (1970). …

Studies of the habituation and sensorimotor gating of startle responses to strong exteroceptive
stimuli provide some unique opportunities for cross-species explorations into information …

Rationale: Sensorimotor gating of the startle reflex can be assessed across species, using
similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a measure of sensorimotor …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …