Single blind randomized phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized …

IM Lips, UA van der Heide, K Haustermans… - Trials, 2011 - Springer
Background The treatment results of external beam radiotherapy for intermediate and high
risk prostate cancer patients are insufficient with five-year biochemical relapse rates of …

IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)

S Rinaldi, PHM Peeters, F Berrino… - Endocrine-related …, 2006 - erc.bioscientifica.com
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor
binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in …

A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective …

FL Crowe, TJ Key, NE Allen, PN Appleby… - Annals of human …, 2011 - Taylor & Francis
Background: Height and BMI are risk factors for several types of cancer and may be related
to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with …

The Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion (UMBRELLA): objectives, design, and baseline results

DA Young-Afat, CH Van Gils… - Breast cancer research …, 2017 - Springer
Purpose In oncology, RCTs are often beset by slow recruitment, limited generalizability, and
strong preferences for interventions by patients and physicians. The cohort multiple …

Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women

M Chavez-MacGregor, CH Van Gils… - Breast cancer research …, 2008 - Springer
Objective Lifetime cumulative number of menstrual cycles is related to breast cancer risk.
The aim of this study is to investigate the relation between this index and serum sex hormone …

Physical activity levels of women with breast cancer during and after treatment, a comparison with the Dutch female population

R Gal, EM Monninkhof, PHM Peeters… - Acta …, 2019 - Taylor & Francis
Background: Physical activity has been shown to reduce side-effects of breast cancer and its
treatment. As physical activity levels of patients with breast cancer are largely unknown, we …

Patient-reported cosmetic satisfaction and the long-term association with quality of life in irradiated breast cancer patients

MCT Batenburg, ML Gregorowitsch, W Maarse… - Breast cancer research …, 2020 - Springer
Purpose To evaluate patient-reported cosmetic satisfaction in women treated with radiation
therapy for breast cancer and to determine the association between dissatisfaction and …

The effects of exercise on the quality of life of patients with breast cancer (the UMBRELLA Fit study): study protocol for a randomized controlled trial

R Gal, EM Monninkhof, RHH Groenwold, CH van Gils… - Trials, 2017 - Springer
Background Meta-analyses of randomized controlled trials (RCTs) have shown that exercise
has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these …

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

ML Gregorowitsch, H van den Bongard… - Breast cancer research …, 2018 - Springer
Purpose Ductal carcinoma in situ (DCIS) is associated with an excellent prognosis; historical
studies have shown similar levels of psychological distress in patients with DCIS and with …

Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

R Gal, EM Monninkhof, CH van Gils… - Breast cancer research …, 2021 - Springer
Purpose The Trials within Cohorts (TwiCs) design aims to overcome problems faced in
conventional RCTs. We evaluated the TwiCs design when estimating the effect of exercise on …