Health professionals are encouraged to take the Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

Methods The Medline Literature Database from January 1966 to June 1995 was searched
using the medical subject headings heart failure (congestive), cardiomyopathy (congestive), …

Background Several clinical trials have reported inconsistent findings for the effect of fibrates
on cardiovascular risk. We undertook a systematic review and meta-analysis to investigate …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background— For the general population, the clinical relevance of an increased urinary
albumin excretion rate is still debated. Therefore, we examined the relationship between urinary …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Background Severe hypoglycemia may increase the risk of a poor outcome in patients with
type 2 diabetes assigned to an intensive glucose-lowering intervention. We analyzed data …

In this paper the Rotterdam Elderly Study is presented. The aim of the study is to investigate
determinants of disease occurrence and progression in the elderly. In addition to …

Hillege HL, Janssen WMT, Bak AAA, Diercks GFH, Grobbee DE, Crijns HJGM, van Gilst WH,
de Zeeuw D, de Jong PE for the PREVEND Study group (University of Groningen and …

Cerebral white matter lesions are a common finding on MRI in elderly persons. We studied
the prevalence of white matter lesions and their relation with classic cardiovascular risk …