Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties and…

The pulmonary surfactant system: biochemical and clinical aspects

L Creuwels, LMG Van Golde, HP Haagsman - Lung, 1997 - Springer
This article starts with a brief account of the history of research on pulmonary surfactant. We
will then discuss the morphological aspects and composition of the pulmonary surfactant …

[HTML][HTML] Role of pulmonary surfactant components in surface film formation and dynamics

EJA Veldhuizen, HP Haagsman - Biochimica et biophysica acta (bba) …, 2000 - Elsevier
Pulmonary surfactant is a mixture of lipids and proteins which is secreted by the epithelial
type II cells into the alveolar space. Its main function is to reduce the surface tension at the air/…

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

AA Pezzulo, XX Tang, MJ Hoegger, MH Abou Alaiwa… - Nature, 2012 - nature.com
Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene 1 . Although bacterial lung infection and …

Carvacrol Induces Heat Shock Protein 60 and Inhibits Synthesis of Flagellin in Escherichia coli O157:H7

SA Burt, R van der Zee, AP Koets… - Applied and …, 2007 - Am Soc Microbiol
The essential oils of oregano and thyme are active against a number of food-borne
pathogens, such as Escherichia coli O157:H7. Carvacrol is one of the major antibacterial …

Structural requirements for the antimicrobial activity of carvacrol

EJA Veldhuizen… - Journal of agricultural …, 2006 - ACS Publications
Carvacrol is a component of several essential oils and has been shown to exert antimicrobial
activity. The structural requirements for the activity of carvacrol were determined by …

Increase in activity of essential oil components carvacrol and thymol against Escherichia coli O157: H7 by addition of food stabilizers

SA Burt, R Vlielander, HP Haagsman… - Journal of food …, 2005 - Elsevier
The major components of oregano and thyme essential oils that had previously been shown
to inhibit Escherichia coli O157:H7 were determined by high-performance liquid …

Pulmonary surfactant protein A enhances the host-defense mechanism of rat alveolar macrophages

F van Iwaarden, B Welmers, J Verhoef… - Am J Respir Cell Mol …, 1990 - atsjournals.org
In 1973, La Force and associates (1) reported enhanced killing ofStaphylococcus aureus by
alveolar macrophages in the presence of surfactant and postulated a role fur surfactant in …

Surfactant-associated proteins: functions and structural variation

HP Haagsman, RV Diemel - … Biochemistry and Physiology Part A: Molecular …, 2001 - Elsevier
Pulmonary surfactant is a barrier material of the lungs and has a dual role: firstly, as a true
surfactant, lowering the surface tension; and secondly, participating in innate immune defence …

Avian defensins

A van Dijk, EJA Veldhuizen, HP Haagsman - Veterinary Immunology and …, 2008 - Elsevier
Modulation of defensin expression may be one way to improve animal health and to reduce
zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic …