Our view of biological membranes has evolved dramatically over the last few decades. In
the bilayer model from Singer & Nicholson (Science 1972;175:720–731), both proteins and …

Lipids were long believed to have a structural role in biomembranes and a role in energy
storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last decades …

A WIDE variety of membrane transformations important in intracellular transport are inhibited
by the fungal metabolite brefeldin A (refs 1–4), implying that the target for this drug is central …

The lysosomal degradation pathway of autophagy has a crucial role in defence against
infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce …

Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the
immune response and the development of metabolic syndrome. Most of the retinol present …

Coatomer, a complex of seven proteins, appears to be the precursor of the coat structure of
non-clathrin-coated Golgi-derived vesicles. Another component of this vesicle coat is the …

Mobilization of fatty acids from adipose tissue during metabolic stress will increase the amount
of free fatty acids in blood and follicular fluid and, thus, may affect oocyte quality. In this in …

The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation
factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is …

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer's
disease (AD) may arise from altered cholesterol metabolism, although the molecular …

In higher eukaryotes, phospholipid and cholesterol synthesis occurs mainly in the endoplasmic
reticulum, whereas sphingomyelin and higher glycosphingolipids are synthesized in the …