Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

The cerebellum is best known for its role in controlling motor behaviors. However, recent
work supports the view that it also influences non-motor behaviors. The contribution of the …

Cerebellar high-frequency oscillations have been observed for many decades, but their
underlying mechanisms have remained enigmatic. In this issue of Neuron, two papers indicate …

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed
to be required for cerebellar motor learning. To date, tests of this hypothesis have sought …

Context The recent focus on the development of preventive interventions for Alzheimer disease
has fueled the search for biomarkers of presymptomatic disease. Patients with Alzheimer …

10.7554/eLife.02536.001 Due to the uniform cyto-architecture of the cerebellar cortex, its
overall physiological characteristics have traditionally been considered to be homogeneous. In …

Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we
understand little of how inhibitory interneurons contribute to cerebellar function in behaving …

Cerebellar motor learning is required to obtain procedural skills. Studies have provided
supportive evidence for a potential role of kinase-mediated long-term depression (LTD) at the …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein SHANK2
are a highly penetrant cause of autism spectrum disorders (ASD) involving cerebellum-…

Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber
(PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have …