Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes,
but also an important component of the cytoskeleton in astrocytes during development. …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (…

Context Cognitive decline, mood, behavioral and sleep disturbances, and limitations of
activities of daily living commonly burden elderly patients with dementia and their caregivers. …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is changing…

The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the
presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads. …

Introduction Microglia are tissue macrophages of the central nervous system that monitor brain
homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration …

Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human
brain. The current consensus is that cerebral organoids consist of cells derived from the …

Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's
disease (AD). Yet, not much is known about the molecular alterations underlying this reactive …