Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by
recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes …

Microarray analysis has become a widely used tool for the generation of gene expression data
on a genomic scale. Although many significant results have been derived from microarray …

Genome-wide expression analysis was used to identify genes whose expression depends
on the functions of key components of the transcription initiation machinery in yeast. …

Defining protein complexes is critical to virtually all aspects of cell biology. Two recent affinity
purification/mass spectrometry studies in Saccharomyces cerevisiae have vastly increased …

We have designed a doxycycline‐regulated form of the H1 promoter of RNA polymerase III
that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). …

Metastasis is the process by which cancers spread to distinct sites in the body. It is the
principal cause of death in individuals suffering from cancer. For some types of cancer, early …

Eukaryotic genomes are packaged into nucleosomes, which are thought to repress gene
expression generally 1 , 2 , 3 . Repression is particularly evident at yeast telomeres, where …

The transcription factors TFIID and SAGA are multi-subunit complexes involved in transcription
by RNA polymerase II 1 , 2 . TFIID and SAGA contain common TATA-binding protein (TBP…

To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …

Human embryos frequently harbor large-scale complex chromosomal errors that impede
normal development. Affected embryos may fail to implant although many first breach the …