The postsynaptic architecture of excitatory synapses: a more quantitative view

M Sheng, CC Hoogenraad - Annu. Rev. Biochem., 2007 - annualreviews.org
Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic
spines, a postsynaptic microcompartment that also harbors organelles involved in protein …

Building the neuronal microtubule cytoskeleton

LC Kapitein, CC Hoogenraad - Neuron, 2015 - cell.com
Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity, and …

Actin in dendritic spines: connecting dynamics to function

P Hotulainen, CC Hoogenraad - Journal of Cell Biology, 2010 - rupress.org
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing and …

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

J Jaworski, LC Kapitein, SM Gouveia, BR Dortland… - Neuron, 2009 - cell.com
Dendritic spines are the major sites of excitatory synaptic input, and their morphological
changes have been linked to learning and memory processes. Here, we report that growing …

Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)

T Stepanova, J Slemmer, CC Hoogenraad… - Journal of …, 2003 - Soc Neuroscience
Several microtubule binding proteins, including CLIP-170 (cytoplasmic linker protein-170),
CLIP-115, and EB1 (end-binding protein 1), have been shown to associate specifically with …

Control of dendritic arborization by the phosphoinositide-3′-kinase–Akt–mammalian target of rapamycin pathway

J Jaworski, S Spangler, DP Seeburg… - Journal of …, 2005 - Soc Neuroscience
The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt–…

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

F Hellal, A Hurtado, J Ruschel, KC Flynn, CJ Laskowski… - Science, 2011 - science.org
Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for
spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, …

[HTML][HTML] Clasps are CLIP-115 and-170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts

A Akhmanova, CC Hoogenraad, K Drabek… - Cell, 2001 - cell.com
CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the
ends of growing microtubules and may act as anti-catastrophe factors. Here, we have isolated …

Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum* S

D Cheng, CC Hoogenraad, J Rush, E Ramm… - Molecular & cellular …, 2006 - ASBMB
The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic
signaling, and its components are heterogeneous among different neuronal subtypes and …

Microcircuitry and function of the inferior olive

CI De Zeeuw, CC Hoogenraad, SKE Koekkoek… - Trends in …, 1998 - cell.com
The inferior olive, which provides the climbing fibers to Purkinje cells in the cerebellar cortex,
has been implicated in various functions, such as learning and timing of movements, and …