In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from
an intracellular location to the cell surface, where it facilitates the reduction of plasma …

Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues — prominently in muscle, fat and liver — is one of the earliest manifestations of a …

Unlike in the ocean basins where the shallow mantle eventually contributes to the destruction
of the overlying crust, the shallow mantle beneath continents serves as a stiff, buoyant “root…

At least three different glucose transport systems exist in mammalian cells. These are: (1) the
constitutively active, facilitative carrier characteristic of human erythrocytes 1 , Hep G2 (ref. 2…

High levels of dietary fat may contribute to both insulin resistance and obesity in humans but
evidence is limited. The euglycemic clamp technique combined with tracer administration …

Antibodies specific for the insulin-regulatable glucose transporter (GLUT 4) were used to
immunolocalize this protein in brown adipose tissue from basal- and insulin-treated rats. …

A MAJOR mechanism by which insulin stimulates glucose transport in muscle and fat is the
translocation of glucose transporters from an intracellular membrane pool to the cell surface 1…

Berberine has been shown to have antidiabetic properties, although its mode of action is not
known. Here, we have investigated the metabolic effects of berberine in two animal models …

Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known
regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 …

OBJECTIVE—Berberine (BBR) activates AMP-activated protein kinase (AMPK) and improves
insulin sensitivity in rodent models of insulin resistance. We investigated the mechanism of …