Background. Hypoxia develops in tumors because of a less ordered, often chaotic, and leaky
vascular supply compared with that in normal tissues. In preclinical models, hypoxia has …

Portal vein thrombosis (PVT) is a rare disorder that is associated with a variety of underlying
conditions, of which liver cirrhosis, malignancy and myeloproliferative disorders are the most …

Thrombosis involving the liver vasculature is rare but constitutes a potentially life-threatening
situation. Budd-Chiari syndrome (BCS) is characterised by thrombosis of the hepatic …

Background Micro RNA ‐122 (miR‐122) is an important host factor for hepatitis C virus
replication. Administration of miravirsen, an anti‐miR‐122 oligonucleotide, resulted in a dose …

Interferon alfa (IFN-α) is the primary treatment for chronic hepatitis B. The standard duration
of IFN-α therapy is considered 16 weeks; however, the optimal treatment length is still poorly …

Background: Through 5 years of treatment with tenofovir disoproxil fumarate (TDF) in mostly
naïve patients, we reported sustained viral suppression with regression of fibrosis, and …

We studied the etiology, diagnosis and natural course of myeloproliferative disease (MPD) in
40 consecutive patients with Budd-Chiari syndrome (BCS). In 38% of the BCS patients with …

Background Direct-acting antivirals for chronic hepatitis C (HCV) infection have reduced the
need for on-treatment HCV RNA monitoring. We assessed the accuracy and cost …

Purpose: To determine the role of DNA repair in hypoxic radioresistance. Methods and
Materials: Chinese hamster cell lines with mutations in homologous recombination (XRCC2, …

The aetiology of portal vein thrombosis (PVT) is heterogeneous. Important primary risk
factors for PVT are cirrhosis, hepatobiliary malignancies and pancreatitis. Newly discovered …