The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action
ELM Vansterkenburg, I Coppens, J Wilting, OJM Bos… - Acta tropica, 1993 - Elsevier
In plasma, a significant part of suramin circulates in tight association with low-density lipoproteins
(LDL). At therapeutically obtainable concentrations (100 μM) of suramin, about 85% of …
(LDL). At therapeutically obtainable concentrations (100 μM) of suramin, about 85% of …
Convergence properties of free energy calculations:. Alpha.-cyclodextrin complexes as a case study
AE Mark, SP van Helden, PE Smith… - Journal of the …, 1994 - ACS Publications
By considering all possible mutations among four para-substituted phenols, p-chlorophenol,
p-methylphenol, p-cyanophenol, and p-methoxyphenol, which bind as inclusion …
p-methylphenol, p-cyanophenol, and p-methoxyphenol, which bind as inclusion …
The molecular mechanism of the neutral-to-base transition of human serum albumin: Acid/Base titration and proton nuclear magnetic resonance studies on a large …
OJM Bos, JFA Labro, MJE Fischer, J Wilting… - Journal of Biological …, 1989 - Elsevier
In order to obtain a better understanding of the neutral-to-base (NB) transition of human
serum albumin, we performed acid/base titration experiments and 500-MHz 1 H NMR …
serum albumin, we performed acid/base titration experiments and 500-MHz 1 H NMR …
Reductive activation of potential antitumor mitosene compounds
M Maliepaard, NJ de Mol, LHM Janssen… - Journal of medicinal …, 1993 - ACS Publications
The reductive activation of mitosene compounds was studied with cyclic voltammetry and
HPLC analysis. Reduction of mitosenes, possessing good leaving groups at Cl and C-10, was …
HPLC analysis. Reduction of mitosenes, possessing good leaving groups at Cl and C-10, was …
Structure‐activity relationships between antibacterial activities and physicochemical properties of sulfonamides
MJB Mengelers, PE Hougee… - Journal of veterinary …, 1997 - Wiley Online Library
Relationships between the antimicrobial activities of sulfonamides and physico‐chemical
properties including the acid dissociation constant (pK a ) and the hydrophobicity constant (π) …
properties including the acid dissociation constant (pK a ) and the hydrophobicity constant (π) …
The role of protein charge in protein-lipid interactions. pH-dependent changes of the electrophoretic mobility of liposomes through adsorption of water-soluble …
JJ Bergers, MH Vingerhoeds, L van Bloois… - Biochemistry, 1993 - ACS Publications
Revised Manuscript Received February 2, 1993 abstract: The role of electrostatics in the
adsorption process of proteins to preformed negatively-charged (phosphatidylcholine/…
adsorption process of proteins to preformed negatively-charged (phosphatidylcholine/…
Location and characterization of the warfarin binding site of human serum albumin: a comparative study of two large fragments
OJM Bos, JPM Remijn, MJE Fischer, J Wilting… - Biochemical …, 1988 - Elsevier
… Bos OJM, Fischer MJE, Wilting J and Janssen LHM, Drug binding and other … Wilting J, van
der Giesen WF and Janssen LHM, The effect of chloride on the binding of warfarin to albumin …
der Giesen WF and Janssen LHM, The effect of chloride on the binding of warfarin to albumin …
pK change of imidazole groups in bovine serum albumin due to the conformational change at neutral pH
SH De Bruin, BJM Harmsen, LHM Janssen… - Biochemistry, 1971 - ACS Publications
pK change of imidazole groups in bovine serum albumin due to the conformational change at
neutral pH Page 1 IMIDAZOLE GROUPS IN SERUM ALBUMIN and Blout, E. R. (1971), J. Amer …
neutral pH Page 1 IMIDAZOLE GROUPS IN SERUM ALBUMIN and Blout, E. R. (1971), J. Amer …
Drug-binding and other physicochemical properties of a large tryptic and a large peptic fragment of human serum albumin
OJM Bos, MJE Fischer, J Wilting… - Biochimica et Biophysica …, 1988 - Elsevier
The diazepam-binding behaviour of a large tryptic and a large peptic fragment of human
serum albumin has been studied by circular dichroism and equilibrium dialysis in order to …
serum albumin has been studied by circular dichroism and equilibrium dialysis in order to …
Electrochemistry of potentially bioreductive alkylating quinones: Part 3. Quantitative structure-electrochemistry relationships of aziridinylquinones
RJ Driebergen, EE Moret, LHM Janssen, JS Blauw… - Analytica chimica …, 1992 - Elsevier
The concept of bioreductive alkylation as a mechanism of action of aziridinylquinoid
anticancer agents has been investigated by the use of electrochemical techniques. Properly …
anticancer agents has been investigated by the use of electrochemical techniques. Properly …