Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice

JWM Höppener, HS Jansz, C Oosterwijk… - Journal of cellular …, 1994 - Wiley Online Library
Islet amyloid polypeptide (“amylin”) is the major protein component of amyloid deposits in
pancreatic islets of type 2 (non‐insulin‐dependent) diabetic patients. Islet amyloid polypeptide …

Single-stranded DNA phage origins

PD Baas, HS Jansz - The Molecular Biology of Bacterial Virus Systems, 1988 - Springer
… Fluit AC, Baas PD, Jansz HS (1986) Termination and reinitiation signals of bacteriophage~
X174 rolling circle DNA replication. Virology 154: 357-368 Francke B, Ray DS (1971) Formation …

A second human calcitonin/CGRP gene

PH Steenbergh, JWM Höppener, J Zandberg… - FEBS …, 1985 - Wiley Online Library
The calcitonin (CT) gene is alternatively expressed in a tissue‐specific fashion producing
either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene …

Structure and expression of the human calcitonin/CGRP genes

PM Steenbergh, JWM Höppener, J Zandberg… - FEBS …, 1986 - Wiley Online Library
Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene‐related
peptide (hCGRP‐II) [(1985) FEBS Lett. 183, 403‐407]. In this report we describe …

Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked …

JWM Höppener, JS Verbeek, EJP De Koning… - Diabetologia, 1993 - Springer
Type 2 (non-insulin-dependent) diabetes mellitus is characterised by hyperglycaemia,
peripheral insulin resistance, impaired insulin secretion and pancreatic islet amyloid formation. …

The complete islet amyloid polypeptide precursor is encoded by two exons

S Mosselman, JWM Höppener, CJM Lips… - FEBS …, 1989 - Wiley Online Library
Islet amyloid polypeptide (IAPP) is the 37‐amino acid peptide subunit of amyloid found in
pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the …

Islet amyloid polypeptide: identification and chromosomal localization of the human gene

S Mosselman, JWM Höppener, J Zandberg… - FEBS …, 1988 - Wiley Online Library
Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from
pancreatic amyloid. Here, we describe the isolation and partial characterization of the human …

Expression of insulin‐like growth factor‐I and‐II genes in human smooth muscle tumours.

JW Höppener, S Mosselman, PJ Roholl… - The EMBO …, 1988 - embopress.org
The insulin‐like growth factors I and II (IGF‐I and ‐II) are polypeptides which play an important
role in growth and development of the organism. In the present report we describe the …

Nucleotide sequence of the origin of replication in bacteriophage ΦX174 RF DNA

SA Langeveld, ADM Van Mansfeld, PD Baas, HS Jansz… - Nature, 1978 - nature.com
The gene A protein of bacteriophage ΦX174 has been used in vitro to convert ΦX RFI DNA
into the relaxed RFII form by nicking the viral strand. The nucleotide sequence at the 3′ end …

Amylin-induced in vivo insulin resistance in conscious rats: the liver is more sensitive to amylin than peripheral tissues

SJ Koopmans, ADM Van Mansfeld, HS Jansz… - Diabetologia, 1991 - Springer
Amylin is a polypeptide of 37 amino acids, predominantly synthesized in pancreatic Beta
cells. The peptide was suggested to be dysregulated in Type 2 (non-insulin-dependent) …