… M, Groenewegen WA, Allessie MA, Jongsma HJ. Altered pattern of connexin40 distribution
in … AJ, van Veen TAA, Allessie MA, Jongsma HJ. Gap junctional remodeling in relation to …

Genetic approaches have succeeded in defining the molecular basis of an increasing array
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes, …

In heart, the propagation of electrical activity is mediated by intercellular channels, referred
to as junctional channels, aggregated into gap junctions and localised between myocytes. …

Background— Prolonged atrial fibrillation (AF) results in electrical, structural, and gap-junctional
remodeling. We examined the reversibility of the changes in (ultra)structure and gap …

Objective: It has been postulated that high atrial rate induced changes at the level of the gap
junctions (‘gap junctional remodeling’, ie changes in distribution, intercellular orientation …

Atrial standstill (AS) is a rare arrhythmia that occasionally appears to be genetically determined.
This study investigates the genetic background of this arrhythmogenic disorder in a …

Background— Connexin 43 (Cx43) is a major determinant of conduction in the ventricular
working myocardium of mammals. We investigated the effect of decreased Cx43 expression …

Cardiac conduction defects associate with mutations in SCN5A, the gene encoding the cardiac
Na + channel. In the present study, we characterized a family in which the proband was …

Cultures of neonatal rat heart cells contain predominantly myocytes and fibroblastic cells.
Most abundant are groups of synchronously contracting myocytes, which are electrically well …

Background: Primary dysrhythmias other than those associated with the long QT syndrome,
are increasingly recognized. One of these are represented by patients with a history of …