Objective The initial hypothesis that schizophrenia is a manifestation of hyperdopaminergia
has recently been faulted. However, several new findings suggest that abnormal, although …

There is consistent evidence that brain volume changes in early and late life. Most longitudinal
studies usually only span a few years and include a limited number of participants. In this …

The hypothalamus-pituitary-adrenal (HPA) axis and its end product cortisol are essential for
an adequate response to stress. Considering the role of stress as a risk factor for psychiatric …

Objective. So far, there have been no attempts to integrate the growing number of all brain
volumetric magnetic resonance imaging studies in depression. In this comprehensive meta‐…

Objective To determine the US national prevalence of attention-deficit/hyperactivity disorder
(ADHD) and whether prevalence, recognition, and treatment vary by socioeconomic group. …

Objective: Cognitive impairment, manifested as mild to moderate deviations from psychometric
norms, is present in many but not all schizophrenia patients. The purpose of the present …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

OBJECTIVE: Memory impairment is well documented in schizophrenia. Less is known, however,
about the exact magnitude, pattern, and extent of the impairment. The effect of potential …