Central nervous system tumours represent one of the most lethal cancer types, particularly
among children 1 . Primary treatment includes neurosurgical resection of the tumour, in which …

In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Experimental
in vitro models that faithfully capture the hallmarks and tumor heterogeneity of OC are …

Complex learning aims at the integration of knowledge, skills, and attitudes; the coordination
of qualitatively different constituent skills; and the transfer of what is learned to daily life or …

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are …

Single-cell transcriptomics has recently emerged as a powerful technology to explore gene
expression heterogeneity among single cells. Here we identify two major sources of …

In a flipped classroom, students study instructional material before class and apply this
material during class. To provide a statistical synthesis of current research on effects of flipped …

Single-cell genomics and single-cell transcriptomics have emerged as powerful tools to
study the biology of single cells at a genome-wide scale. However, a major challenge is to …

Research indicates that effective instructional methods for practicing simple tasks differ from
effective methods for complex tasks. But unfortunately, load‐reducing methods that work …

Orientation of cell divisions is a key mechanism of tissue morphogenesis. In the growing
Drosophila wing imaginal disc epithelium, most of the cell divisions in the central wing pouch …