This review addresses the possible consequences of a mismatch in length between the
hydrophobic part of membrane-spanning proteins and the hydrophobic bilayer thickness for …

Membrane proteins present a hydrophobic surface to the surrounding lipid, whereas portions
protruding into the aqueous milieu expose a polar surface. But how have proteins evolved …

Nonbilayer lipids can be defined as cone-shaped lipids with a preference for nonbilayer
structures with a negative curvature, such as the hexagonal phase. All membranes contain …

A major obstacle in the study of membrane proteins is their solubilization in a stable and
active conformation when using detergents. Here, we explored a detergent-free approach to …

There are many ways in which lipids can modulate the activity of membrane proteins.
Simply a change in hydrophobic thickness of the lipid bilayer, for example, already can have …

Fibrillar protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be
involved in death of the insulin-producing islet β cells in type 2 diabetes mellitus. It has been …

We have investigated the effect of several hydrophobic polypeptides on the phase behavior
of diacylphosphatidylcholines with different acyl chain length. The polypeptides are …

Specific interactions of membrane proteins with the membrane interfacial region potentially
define protein position with respect to the lipid environment. We investigated the proposed …

A new and promising tool in membrane research is the detergent-free solubilization of
membrane proteins by styrene–maleic acid copolymers (SMAs). These amphipathic molecules …

Biological membranes are characterized by a heterogeneous composition, which is not only
manifested in the wide variety of their components, but also in aspects like the lateral …