Targeting chemokines and chemokine receptors with antibodies
A Klarenbeek, D Maussang, C Blanchetot… - Drug Discovery Today …, 2012 - Elsevier
Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical
and biotechnology companies. In particular, industrial development pipelines are filled with …
and biotechnology companies. In particular, industrial development pipelines are filled with …
Transmission of Mycobacterium pinnipedii to humans in a zoo with marine mammals
A Kiers, A Klarenbeek, B Mendelts… - … of Tuberculosis and …, 2008 - ingentaconnect.com
OBJECTIVES: An outbreak of tuberculosis (TB) in sea lions occurred recently in a zoo in the
Netherlands. The disease was detected in a captive colony consisting of 29 animals kept in …
Netherlands. The disease was detected in a captive colony consisting of 29 animals kept in …
[HTML][HTML] Communication practices in conversations about sexual health in medical healthcare settings: A systematic review
I Kelder, P Sneijder, A Klarenbeek, E Laan - Patient Education and …, 2022 - Elsevier
Objective Many healthcare professionals experience difficulties in discussing sexual health
with their patients. The aim of this review was to synthesize results of studies on …
with their patients. The aim of this review was to synthesize results of studies on …
[HTML][HTML] Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector …
V Bobkov, AM Zarca, A Van Hout, M Arimont… - Biochemical …, 2018 - Elsevier
Upregulation of the chemokine receptor CXCR4 contributes to the progression and
metastasis of both solid and hematological malignancies, rendering this receptor an attractive …
metastasis of both solid and hematological malignancies, rendering this receptor an attractive …
Age-related changes in plasma biomarkers and their association with mortality in COVID-19
EHA Michels, B Appelman… - European …, 2023 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …
in older patients. Several immunomodulating therapies seem less beneficial in these …
The role of endotoxin in the pathogenesis of acute bovine laminitis
R Boosman, C Mutsaers, A Klarenbeek - Veterinary Quarterly, 1991 - Taylor & Francis
To study the possible role of endotoxin in the pathogenesis of bovine laminitis, local and
systemic injections of endotoxin (E. coli 0111 B4) with different doses were given to three …
systemic injections of endotoxin (E. coli 0111 B4) with different doses were given to three …
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform
A Klarenbeek, KE Mazouari, A Desmyter, C Blanchetot… - MAbs, 2015 - Taylor & Francis
Camelid immunoglobulin variable (IGV) regions were found homologous to their human
counterparts; however, the germline V repertoires of camelid heavy and light chains are still …
counterparts; however, the germline V repertoires of camelid heavy and light chains are still …
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
A Van Hout, A Klarenbeek, V Bobkov, J Doijen… - Biochemical …, 2018 - Elsevier
The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human
diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, …
diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, …
Concurrent immune suppression and hyperinflammation in patients with community-acquired pneumonia
X Brands, BW Haak, AM Klarenbeek, NA Otto… - Frontiers in …, 2020 - frontiersin.org
Background The nature and timing of the host immune response during infections remain
uncertain and most knowledge is derived from critically ill sepsis patients. We aimed to test the …
uncertain and most knowledge is derived from critically ill sepsis patients. We aimed to test the …
[HTML][HTML] Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide
L Pereverzeva, CCA van Linge, AR Schuurman… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Most macrophages generate energy to mount an inflammatory cytokine response by increased
glucose metabolism through intracellular glycolysis. Previous studies have suggested …
glucose metabolism through intracellular glycolysis. Previous studies have suggested …
