Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular components that …

Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins
characterized by four transmembrane domains. They participate in a variety of cellular …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic, …

Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles
are catabolized 1 , 2 . During starvation, the protein TOR (target of rapamycin), a nutrient…

There is accumulating evidence that glial cells actively modulate neuronal synaptic transmission.
We identified a glia-derived soluble acetylcholine-binding protein (AChBP), which is a …

Background: Sorting nexins (SNXs) are phox homology (PX) domain-containing proteins
thought to regulate endosomal sorting of internalized receptors. The prototypical SNX is sorting …

Although Akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (PI3K)–Akt
pathway do not always induce substantial apoptosis. We show that silencing Akt1 …

Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by
secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the …

A heterotetrameric complex termed AP-3 is involved in signal-mediated protein sorting to
endosomal-lysosomal organelles. AP-3 has been proposed to be a component of a nonclathrin …

The prevailing hypothesis is that the intracellular site of budding of coronaviruses is determined
by the localization of its membrane protein M (previously called E1). We tested this by …