Gebruikersprofielen voor "Klumperman, J. "
![]() | Judith KlumpermanProfessor of Cell Biology Geverifieerd e-mailadres voor umcutrecht.nl Geciteerd door 27258 |
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
P Saftig, J Klumperman - Nature reviews Molecular cell biology, 2009 - nature.com
Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular components that …
extracellular material that has been internalized by endocytosis and intracellular components that …
The complex ultrastructure of the endolysosomal system
J Klumperman, G Raposo - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic, …
network of interacting compartments. Distinct types of endosomes are discerned by kinetic, …
Architecture of the mammalian Golgi
J Klumperman - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Since its first visualization in 1898, the Golgi has been a topic of intense morphological research.
A typical mammalian Golgi consists of a pile of stapled cisternae, the Golgi stack, which …
A typical mammalian Golgi consists of a pile of stapled cisternae, the Golgi stack, which …
Mannose 6–phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6–positive vesicles
J Klumperman, R Kuliawat, JM Griffith… - The Journal of cell …, 1998 - rupress.org
The occurrence of clathrin-coated buds on immature granules (IGs) of the regulated secretory
pathway suggests that specific transmembrane proteins are sorted into these buds through …
pathway suggests that specific transmembrane proteins are sorted into these buds through …
Termination of autophagy and reformation of lysosomes regulated by mTOR
L Yu, CK McPhee, L Zheng, GA Mardones, Y Rong… - Nature, 2010 - nature.com
Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles
are catabolized 1 , 2 . During starvation, the protein TOR (target of rapamycin), a nutrient…
are catabolized 1 , 2 . During starvation, the protein TOR (target of rapamycin), a nutrient…
Association of the AP-3 adaptor complex with clathrin
EC Dell'Angelica, J Klumperman, W Stoorvogel… - Science, 1998 - science.org
A heterotetrameric complex termed AP-3 is involved in signal-mediated protein sorting to
endosomal-lysosomal organelles. AP-3 has been proposed to be a component of a nonclathrin …
endosomal-lysosomal organelles. AP-3 has been proposed to be a component of a nonclathrin …
Coronavirus M proteins accumulate in the Golgi complex beyond the site of virion budding
J Klumperman, JK Locker, A Meijer… - Journal of …, 1994 - Am Soc Microbiol
The prevailing hypothesis is that the intracellular site of budding of coronaviruses is determined
by the localization of its membrane protein M (previously called E1). We tested this by …
by the localization of its membrane protein M (previously called E1). We tested this by …
[HTML][HTML] Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles
JA Martínez-Menárguez, HJ Geuze, JW Slot… - Cell, 1999 - cell.com
We have determined the concentrations of the secretory proteins amylase and chymotrypsinogen
and the membrane proteins KDELr and rBet1 in COPII- and COPI-coated pre-Golgi …
and the membrane proteins KDELr and rBet1 in COPII- and COPI-coated pre-Golgi …
Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins
The adaptor protein (AP) 3 adaptor complex has been implicated in the transport of lysosomal
membrane proteins, but its precise site of action has remained controversial. Here, we …
membrane proteins, but its precise site of action has remained controversial. Here, we …
Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers
D Zeuschner, WJC Geerts, E van Donselaar… - Nature cell …, 2006 - nature.com
Transport from the endoplasmic reticulum (ER) to the Golgi complex requires assembly of the
COPII coat complex at ER exit sites. Recent studies have raised the question as to whether …
COPII coat complex at ER exit sites. Recent studies have raised the question as to whether …