The systemic immune response to trauma: an overview of pathophysiology and treatment
Improvements in the control of haemorrhage after trauma have resulted in the survival of many
people who would otherwise have died from the initial loss of blood. However, the danger …
people who would otherwise have died from the initial loss of blood. However, the danger …
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences
Neutrophils are essential effector cells in the host defense against invading pathogens. Recently,
novel neutrophil functions have emerged in addition to their classical anti-microbial role…
novel neutrophil functions have emerged in addition to their classical anti-microbial role…
Update on neutrophil function in severe inflammation
Neutrophils are main players in the effector phase of the host defense against micro-organisms
and have a major role in the innate immune response. Neutrophils show phenotypic …
and have a major role in the innate immune response. Neutrophils show phenotypic …
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
J Pillay, I Den Braber, N Vrisekoop… - Blood, The Journal …, 2010 - ashpublications.org
Neutrophils are essential effector cells of the innate immune response and are indispensable
for host defense. Apart from their antimicrobial functions, neutrophils inform and shape …
for host defense. Apart from their antimicrobial functions, neutrophils inform and shape …
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
Suppression of immune responses is necessary to limit damage to host tissue during inflammation,
but it can be detrimental in specific immune responses, such as sepsis and antitumor …
but it can be detrimental in specific immune responses, such as sepsis and antitumor …
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
PF Dijkers, RH Medema, JWJ Lammers… - Current Biology, 2000 - cell.com
Cell death is regulated mainly through an evolutionarily conserved form of cell suicide termed
apoptosis [1]. Deregulation of apoptosis has been associated with cancer, autoimmune …
apoptosis [1]. Deregulation of apoptosis has been associated with cancer, autoimmune …
Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1
PF Dijkers, RH Medema, C Pals, L Banerji… - … and cellular biology, 2000 - Taylor & Francis
Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor regulate the
survival, proliferation, and differentiation of hematopoietic lineages. Phosphatidylinositol 3-…
survival, proliferation, and differentiation of hematopoietic lineages. Phosphatidylinositol 3-…
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
E Caldenhoven, J Liden, S Wissink… - Molecular …, 1995 - academic.oup.com
… van de Stolpe A, Caldenhoven E, Raaijmakers JA, van der Saag PT, Koenderman L 1993
Glucocorticoid-mediated repression of intercellular adhesion molecule-l expression in human …
Glucocorticoid-mediated repression of intercellular adhesion molecule-l expression in human …
STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
E Caldenhoven, TB van Dijk, R Solari… - Journal of Biological …, 1996 - jbc.org
The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to
cytokines (interleukin (IL)-5 and −6) and growth factors (epidermal growth factor). Binding of IL-…
cytokines (interleukin (IL)-5 and −6) and growth factors (epidermal growth factor). Binding of IL-…
The neutrophil life cycle
Neutrophils are recognized as an essential part of the innate immune response, but an active
debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the …
debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the …