The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where
action potentials are initiated. Crucial to the function of the AIS is the presence of specific …

Early hypotheses on the pathophysiology of major depression were based on aberrant
intrasynaptic concentrations of mainly the neurotransmitters serotonin and norepinephrine. …

In order to study mechanisms involved in the etiology of human affective disorders, there is
an abundant use of various animal models. Next to genetic factors that predispose for …

The axon initial segment (AIS) is a specialized region in neurons where action potentials
are initiated. It is commonly assumed that this process requires a high density of voltage-gated …

Action potentials are binary signals that transmit information via their rate and temporal pattern.
In this context, the axon is thought of as a transmission line, devoid of a role in neuronal …

The hyperpolarization-activated cation current (I h ) plays an important role in regulating
neuronal excitability, yet its native single-channel properties in the brain are essentially unknown…

Neuronal subthreshold excitability and firing behaviour are markedly influenced by the activation
and deactivation of the somato‐dendritic hyperpolarization‐activated cation current (I h …

Recent hypotheses on the action of antidepressants imply a modulation of excitatory amino
acid transmission. Here, the effects of long‐term antidepressant application in rats with the …

While idiopathic generalized epilepsies are thought to evolve from temporal highly synchronized
oscillations between thalamic and cortical networks, their cellular basis remains poorly …

Rapid energy-efficient signaling along vertebrate axons is achieved through intricate subcellular
arrangements of voltage-gated ion channels and myelination. One recently appreciated …