The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now, …

Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy comprises …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Ependymal tumors across age groups are currently classified and graded solely by histopathology.
It is, however, commonly accepted that this classification scheme has limited clinical …