Abnormal chromosome content — also known as aneuploidy — is the most common characteristic
of human solid tumours. It has therefore been proposed that aneuploidy contributes to…

The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a)
and AFX (FOXO4), are regulated by the phosphoinositide-3-kinase–protein-kinase-B (PI3K–PKB…

The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a
Forkhead factor that regulates longevity in Caenorhabditis elegans 1 , 2 , 3 . Here we show …

Reactive oxygen species are required for cell proliferation but can also induce apoptosis 1 .
In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also …

The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B ( 1 , 2 ) regulates
certain insulin-responsive genes 3 , 4 , but the transcription factors regulated by protein kinase …

Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human
intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, …

The FoxO forkhead transcription factors FoxO4 (AFX), FoxO3a (FKHR. L1), and FoxO1a (FKHR)
represent important physiological targets of phosphatidylinositol-3 kinase (PI3K)/protein …

The cytokine IL-2 plays a very important role in the proliferation and survival of activated T
cells. These effects of IL-2 are dependent on signaling through the phosphatidylinositol 3-…

Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (eg,
translocations, deletions), are commonly found in human tumors and are linked to …