Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding
proteins that have fundamental roles in orchestrating cargo sorting through the membranous …

In this review, we look at the processes that occur ‘behind the scenes’ in Wnt signalling,
within the Wnt-producing cells. The Wnt community has long been focused upon events that …

Wnt glycoproteins are signaling molecules that control a wide range of developmental
processes in organisms ranging from the simple metazoan Hydra to vertebrates. Wnt signaling …

β-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of
the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily …

Wnt proteins are lipid-modified glycoproteins that play a central role in development, adult
tissue homeostasis and disease. Secretion of Wnt proteins is mediated by the Wnt-binding …

Early endosome-to-trans-Golgi network (TGN) transport is organized by the retromer complex.
Consisting of cargo-selective and membrane-bound subcomplexes, retromer coordinates …

Wnt proteins are secreted signaling molecules that play a central role in development and
adult tissue homeostasis. We have previously shown that Wnt signaling requires retromer …

Wnt proteins function as morphogens that can form long-range concentration gradients to
pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved …

In flies and vertebrates, Armadillo/β-catenin forms a complex with Tcf/Lef-1 transcription
factors, serving as an essential co-activator to mediate Wnt signalling. It also associates with …

The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphate-binding
protein (G protein) G o from Caenorhabditis elegans is expressed in most neurons, …