Institutionalized patients with Down syndrome (n= 307) were monitored for 5 to 10 years
prospectively to determine prevalence of Alzheimer-type dementia. Clinical signs, cognitive …

Aflatoxin B 1 (AFB 1 ) biotransformation comprises cytochrome P450-mediated reactions
resulting in hydroxylated and demethylated metabolites as well as AFB 1 epoxides. As the latter …

Objective: To study the effects of prolonged intake of cafetiere coffee, which is rich in the
diterpenes cafestol and kahweol, on serum aminotransferase and lipid concentrations. Design: …

BACKGROUND: Low back pain (LBP) hampers performance and experiencing an episode
of LBP is strongly associated with recurrent episodes. OBJECTIVE: The prevalence of LBP …

Both environmental exposures and genetics are known to play important roles in shaping
human aging. Here we aimed to quantify the relative contributions of environment (referred to …

Between 1988 and 1994, 441 patients were successfully resuscitated outside hospital in the
city of Rotterdam, of whom 276 (63%) were discharged from hospital alive. Long-term …

Objective: This study assessed the percentage and type of congenital anomalies diagnosed
at first-trimester ultrasound (US) scan in a primary care setting without following a …

Differences in the expression and catalytic activity of hepatic biotransformation enzymes
account for species differences in xenobiotic metabolism, including that of aflatoxin B 1 (AFB 1 ). …

Evidence is increasing that mitochondrial dysfunction is involved in amyotrophic lateral
sclerosis, a neurodegenerative disease characterized by selective motoneuron death. To study …

A novel method for measuring nuclear reactions in inverse kinematics with stored ion beams
was successfully used to extract the nuclear-matter radius of Ni 58 . The experiment was …