A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
BJM Braakhuis, MP Tabor, JA Kummer, CR Leemans… - Cancer research, 2003 - AACR
… Tabor MP, Braakhuis BJM, van der Wal JE, van Diest PJ, Leemans CR, Brakenhoff RH,
Kummer JA Comparative molecular and histological grading of epithelial dysplasia of the oral …
Kummer JA Comparative molecular and histological grading of epithelial dysplasia of the oral …
Molecular assays for the diagnosis of minimal residual head-and-neck cancer: methods, reliability, pitfalls, and solutions
VMM van Houten, MP Tabor, MWM van den Brekel… - Clinical cancer …, 2000 - AACR
The prognosis of cancer patients is determined by the radicalness of treatment: residual
tumor cells will grow out and develop in manifest local recurrences,regional recurrences, and …
tumor cells will grow out and develop in manifest local recurrences,regional recurrences, and …
Orphan granzymes find a home
N Bovenschen, JA Kummer - Immunological reviews, 2010 - Wiley Online Library
Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐…
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐…
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
JMM Walboomers, MV Jacobs… - The Journal of …, 1999 - Wiley Online Library
A recent report that 93 per cent of invasive cervical cancers worldwide contain human
papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration events …
papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration events …
Notch1 functions as a tumor suppressor in mouse skin
M Nicolas, A Wolfer, K Raj, JA Kummer, P Mill… - Nature …, 2003 - nature.com
Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many
developmental systems 1, and aberrant Notch signaling is associated with tumorigenesis 2…
developmental systems 1, and aberrant Notch signaling is associated with tumorigenesis 2…
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response
JA Kummer, R Broekhuizen, H Everett… - … of Histochemistry & …, 2007 - journals.sagepub.com
Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by
mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to …
mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to …
[HTML][HTML] Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity
H Watanabe, O Gaide, V Pétrilli, F Martinon… - Journal of Investigative …, 2007 - Elsevier
The inflammasome is a cytosolic protein complex regulating the activation of caspase-1,
which cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active form. The …
which cleaves the pro-inflammatory cytokines IL-1β and IL-18 into their active form. The …
Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications
MP Tabor, RH Brakenhoff, VMM van Houten… - Clinical Cancer …, 2001 - AACR
In 1953, Slaughter et al. [DP Slaughter et al., Cancer (Phila.), 6: 963–968, 1953] proposed
the concept of field cancerization in patients with squamous cell carcinoma of the head and …
the concept of field cancerization in patients with squamous cell carcinoma of the head and …
Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas
VMM Van Houten, PJF Snijders… - … journal of cancer, 2001 - Wiley Online Library
High‐risk human papillomaviruses (HPVs) have been proposed to be associated with a
subset of head and neck cancers (HNSCCs). However, clear biological evidence linking HPV‐…
subset of head and neck cancers (HNSCCs). However, clear biological evidence linking HPV‐…
Performance of immuno–positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in …
PKE Börjesson, YWS Jauw, R Boellaard… - Clinical Cancer …, 2006 - AACR
Purpose: Immuno–positron emission tomography (PET), the combination of PET with monoclonal
antibodies (mAb), is an attractive option to improve tumor detection and to guide mAb-…
antibodies (mAb), is an attractive option to improve tumor detection and to guide mAb-…