Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain and …

CONTEXT: Molecules that are released into biological fluids during matrix metabolism of
articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers …

Haemophilic arthropathy, which shares some clinical and biological injury characteristics
with rheumatoid arthritis, is characterized by two main features: chronic proliferative synovitis …

Objective In mice, CD4+CD25+ regulatory T cells play a pivotal role in preventing autoimmunity.
Regulatory T cells are also present and functional in healthy humans. We investigated …

Collagen molecules in articular cartilage have an exceptionally long lifetime, which makes
them susceptible to the accumulation of advanced glycation end products (AGEs). In fact, in …

Objective Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic
glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage …

Non-enzymic modification of tissue proteins by reducing sugars, the so-called Maillard
reaction, is a prominent feature of aging. In articular cartilage, relatively high levels of the …

A biomechanical failure of the collagen network is postulated in many hypotheses of the
development of osteoarthritis with advancing age. Here we investigate the accumulation of non-…

Background: Treatment strategies for tight control of early rheumatoid arthritis (RA) are highly
effective but can be improved. Objective: To investigate whether adding prednisone, 10 mg/…

OBJECTIVE: Adipose tissue is an endocrine tissue releasing adipokines suggested to be
involved in the pathogenesis of osteoarthritis (OA). Nevertheless, their relative contribution and …