BACKGROUND: During the 1980s, the incidence of primary malignant brain and other
central nervous system tumors (hereafter called brain cancer) was reported to be increasing …

Comorbidity, additional disease beyond the condition under study that increases a patient’s
total burden of illness, is one dimension of health status. For investigators working with …

Brominated flame retardants (BFRs) are a group of compounds that have received much
attention recently due to their similarity with “old” classes of organohalogenated compounds …

Important comorbidities recorded on outpatient claims in administrative datasets may be
missed in analyses when only inpatient care is considered. Using the comorbid conditions …

Background: Overdiagnosis of clinically insignificant prostate cancer is considered a major
potential drawback of prostate-specific antigen (PSA) screening. Quantitative estimates of the …

The ubiquity of microplastics (plastic particles <5 mm, including nanosized plastics <1 µm) in
the global biosphere raises increasing concerns about their implications for human health (…

BACKGROUND: The prostate-specific antigen test was approved by the US Food and Drug
Administration in 1986 to monitor the disease status in patients with prostate cancer and, in …

Over the last few years, increasing evidence has become available that some brominated
flame retardants (BFRs) may have endocrine-disrupting (ED) potencies. The goal of the …

An extensive study was carried out in the Netherlands on the occurrence of a number of
estrogenic compounds in surface water, sediment, biota, wastewater, rainwater and on the …

Background: Radical prostatectomy and external beam radiotherapy are the two major
therapeutic options for treating clinically localized prostate cancer. Because survival is often …