The Aurora kinase family in cell division and cancer
G Vader, SMA Lens - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2008 - Elsevier
The Aurora protein kinase family (consisting of Aurora-A, -B and -C) is an important group of
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …
The chromosomal passenger complex: guiding Aurora-B through mitosis
During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different
processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and …
processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and …
Control of lymphocyte function through CD27–CD70 interactions
SMA Lens, K Tesselaar, MHJ van Oers… - Seminars in …, 1998 - Elsevier
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and
its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 …
its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 …
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates
D Liu, G Vader, MJM Vromans, MA Lampson… - Science, 2009 - science.org
Successful cell division requires that chromosomes attach to opposite poles of the mitotic
spindle (bi-orientation). Aurora B kinase regulates chromosome-spindle attachments by …
spindle (bi-orientation). Aurora B kinase regulates chromosome-spindle attachments by …
[HTML][HTML] Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
SMA Lens, RMF Wolthuis, R Klompmaker… - The EMBO …, 2003 - embopress.org
Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in
human cell division remains elusive. We show that mammalian cells lacking survivin are …
human cell division remains elusive. We show that mammalian cells lacking survivin are …
[HTML][HTML] Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
N Jelluma, AB Brenkman, NJF van den Broek… - Cell, 2008 - cell.com
Maintenance of chromosomal stability relies on coordination between various processes
that are critical for proper chromosome segregation in mitosis. Here we show that monopolar …
that are critical for proper chromosome segregation in mitosis. Here we show that monopolar …
Temporal changes in Hec1 phosphorylation control kinetochore–microtubule attachment stability during mitosis
KF DeLuca, SMA Lens, JG DeLuca - Journal of cell science, 2011 - journals.biologists.com
Precise control of the attachment strength between kinetochores and spindle microtubules
is essential to preserve genomic stability. Aurora B kinase has been implicated in regulating …
is essential to preserve genomic stability. Aurora B kinase has been implicated in regulating …
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis
The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle
microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect …
microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect …
The case for Survivin as mitotic regulator
Survivin has been proposed to inhibit apoptosis and to regulate cell division. However,
controversy still exists as to whether Survivin can indeed execute these distinct functions and if …
controversy still exists as to whether Survivin can indeed execute these distinct functions and if …
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody
The chromosomal passenger complex (CPC) coordinates chromosomal and cytoskeletal
events of mitosis. The enzymatic core of this complex (Aurora‐B) is guided through the mitotic …
events of mitosis. The enzymatic core of this complex (Aurora‐B) is guided through the mitotic …