Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics
RMJ Liskamp, DTS Rijkers, JAW Kruijtzer… - …, 2011 - Wiley Online Library
Despite their enormous diversity in biological function and structure, peptides and proteins
are endowed with properties that have induced and stimulated the development of …
are endowed with properties that have induced and stimulated the development of …
Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies
M Van Dijk, DTS Rijkers, RMJ Liskamp… - Bioconjugate …, 2009 - ACS Publications
In this review, the synthesis and application of biomedical and pharmaceutical polymers
synthesized via the copper(I)-catalyzed alkyne-azide cycloaddition, the thiol−ene reaction, or a …
synthesized via the copper(I)-catalyzed alkyne-azide cycloaddition, the thiol−ene reaction, or a …
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles
CJF Rijcken, F De Lorenzi, I Biancacci… - Advanced drug delivery …, 2022 - Elsevier
Nanomedicines are used to improve the efficacy and safety of pharmacotherapeutic
interventions. Unraveling the biological behavior of nanomedicines, including their biodistribution …
interventions. Unraveling the biological behavior of nanomedicines, including their biodistribution …
Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane α-helical peptides
MRR de Planque, JAW Kruijtzer, RMJ Liskamp… - Journal of Biological …, 1999 - ASBMB
Specific interactions of membrane proteins with the membrane interfacial region potentially
define protein position with respect to the lipid environment. We investigated the proposed …
define protein position with respect to the lipid environment. We investigated the proposed …
Improved targeting of the αvβ3 integrin by multimerisation of RGD peptides
I Dijkgraaf, JAW Kruijtzer, S Liu, AC Soede… - European journal of …, 2007 - Springer
Purpose The integrin α v β 3 is expressed on sprouting endothelial cells and on various
tumour cell types. Due to the restricted expression of α v β 3 in tumours, α v β 3 is considered a …
tumour cell types. Due to the restricted expression of α v β 3 in tumours, α v β 3 is considered a …
Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates
S André, RJ Pieters, I Vrasidas, H Kaltner… - …, 2001 - Wiley Online Library
Galectins are mammalian carbohydrate‐binding proteins that are involved in cell–cell and
cell–matrix adhesion, cell migration, and growth regulation with relevance to inflammation …
cell–matrix adhesion, cell migration, and growth regulation with relevance to inflammation …
Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1, 3-dipolar cycloaddition and their biological evaluation: implications for tumor …
I Dijkgraaf, AY Rijnders, A Soede… - Organic & …, 2007 - pubs.rsc.org
This report describes the design and synthesis of a series of αVβ3 integrin-directed monomeric,
dimeric and tetrameric cyclo[Arg-Gly-Asp-D-Phe-Lys] dendrimers using “click chemistry”. …
dimeric and tetrameric cyclo[Arg-Gly-Asp-D-Phe-Lys] dendrimers using “click chemistry”. …
Islet amyloid polypeptide inserts into phospholipid monolayers as monomer
MFM Engel, HA Yigittop, RC Elgersma… - Journal of Molecular …, 2006 - Elsevier
Amyloid deposits in the pancreatic islets of Langerhans are thought to be a main factor
responsible for death of the insulin-producing islet β-cells in type 2 diabetes. It is hypothesized …
responsible for death of the insulin-producing islet β-cells in type 2 diabetes. It is hypothesized …
[HTML][HTML] Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR
E Strandberg, S Özdirekcan, DTS Rijkers… - Biophysical journal, 2004 - cell.com
Solid-state NMR methods employing 2 H NMR and geometric analysis of labeled alanines (GALA)
were used to study the structure and orientation of the transmembrane α-helical …
were used to study the structure and orientation of the transmembrane α-helical …
Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry
M van Dijk, CF van Nostrum, WE Hennink… - …, 2010 - ACS Publications
Herein we describe the synthesis and rheological characterization of a series of
enzymatically sensitive PEG and peptide-based hydrogels by the Cu(I)-catalyzed 1,3-dipolar …
enzymatically sensitive PEG and peptide-based hydrogels by the Cu(I)-catalyzed 1,3-dipolar …