IMMUNOLOGY TODAY Page 1 IMMUNOLOGY TODAY 10 Ciccone, E., Pende, D., Vitalt, M. et
al. (19921 I. Exp. Med. 176,963~971 15 Dohring, C., Scheidegger, D., Samaridis, J,, (1994) …

The therapeutic and commercial success of monoclonal antibodies (mAbs) has inspired
innovative approaches aimed at increasing their potency and broadening their applicability. …

Objective: We report the characterization of MCLA-117, a novel T cell-redirecting antibody
for acute myeloid leukaemia (AML) treatment targeting CD3 on T cells and CLEC12A on …

Mutations in APC or β-catenin inappropriately activate the transcription factor Tcf4, thereby
transforming intestinal epithelial cells. Here it is shown that one of the target genes of Tcf4 in …

Since targeting of recombinant adenovirus vectors to defined cell types in vivo is a major
challenge in gene therapy and vaccinology, we explored the natural diversity in human …

Peripheral blood leukocytes incubated with a semisynthetic phage antibody library and
fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single-chain Fv …

We have constructed a large (3.6×10 8 clones) phage display library of human single chain
Fv (scFv) antibody fragments by combining 49 germlineV H genes with synthetic heavy …

Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells
and have predictive value supporting personalized medicine. Here we describe a large-…

The number of therapeutic monoclonal antibodies in production is expected to rise rapidly
in the next few years. As a result, there is much focus on the optimization of antibody …

This report describes the construction of leucine zipper-based dimerization cassettes for the
conversion of recombinant monomeric scFv antibody fragments to bivalent and bispecific …