The base sequence of DNA provides the genetic code for proteins. The regulation of
expression or suppression of gene transcription is largely determined by the structure of the …

In a prospective study of melioidosis in northern Australia, 252 cases were found over 10
years. Of these, 46% were bacteremic, and 49 (19%) patients died. Despite administration of …

The role of histone deacetylases (HDAC) and the potential of these enzymes as therapeutic
targets for cancer, neurodegenerative diseases and a number of other disorders is an area …

Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15–40%
of breast cancers and that overexpression is associated with poor prognosis. In the …

We present single-molecule, real-time sequencing data obtained from a DNA polymerase
performing uninterrupted template-directed synthesis using four distinguishable fluorescently …

Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …

The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused
by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent …

Objective To provide an update on key safety metrics after transfusion of convalescent plasma
in hospitalized coronavirus 2019 (COVID-19) patients, having previously demonstrated …

Histone deacetylases (HDACs) mediate changes in nucleosome conformation and are
important in the regulation of gene expression 1 . HDACs are involved in cell-cycle progression …