Objective To review the epidemiological and experimental data concerning iron and the
development of atherosclerosis and ischemic heart disease. Data Sources The English-…

In this review a broad overview of historical and current methods for the assessment of iron
bioavailability was given. These methods can be divided into iron solubility studies, iron …

Reactive oxygen species (ROS) have been implicated in the pathophysiology of a large
number of diseases, and can be harmful due to their high reactivity and deleterious effects on …

Objectives Critically ill patients often are anemic, which may impair oxygen delivery.
Transfusion of red cells and supplementation with vitamins or iron are the usual therapeutic …

Background—The genetic background of hereditary hemochromatosis (HH) is homozygosity
for a cysteine-to-tyrosine transition at position 282 in the HFE gene. Heterozygosity for HH …

Objective To investigate mechanisms underlying cartilage damage caused by brief exposure
of cartilage to blood, such as that occurring during intraarticular bleeding. Methods Human …

… 1 Biesma DH, Van de Wiel A, Beguin Y, Kraayenhagen R, Marx JJM. Post-operative
erythropoesis is limited by the inflammatory effect of surgery on iron metabolism. Eur J Clin Invest …

… 3 Kooistra MP, Marx JJM. The absorption of iron is disturbed in recombinant human
erythropoietin-treated peritoneal dialysis patients. Nephrol Dial Transplant 1998;13:2578–84. …

Since the discovery of the hemochromatosis gene (HFE) in 1996, several novel gene defects
have been detected, explaining the mechanism and diversity of iron-overload diseases. At …

Both anaemia of iron deficiency and anaemia of chronic disease are frequently encountered
in inflammatory bowel disease. Anaemia of iron deficiency is mostly due to inadequate …