Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding
cassette transporters, which are capable of pumping a wide variety of endogenous and …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury
(DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable …

Peptide-receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs such
as octreotide is an effective therapy against neuroendocrine tumors. Other radiolabeled …

The Breast Cancer Resistance Protein (BCRP/ABCG2) is a transporter restricting absorption
and enhancing excretion of many compounds including anticancer drugs. This transporter …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long-term …

Different gene-silencing methods, like antisense and short interfering RNA (siRNA), are
widely used as experimental tools to inhibit gene expression. In the present study, the in vivo …

Ischemic preconditioning (IPC) is a potent renoprotective strategy which has not yet been
translated successfully into clinical practice, in spite of promising results in animal studies. We …

▪ Abstract Multiple organic anion transporters in the proximal tubule of the kidney are
involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these …

Reabsorption of filtered solutes from the glomerular filtrate and excretion of waste products
and xenobiotics are the main functions of the renal proximal tubular (PT) epithelium. A human …

Cysteamine is an amino thiol with the chemical formula HSCH 2 CH 2 NH 2 . Endogenously,
cysteamine is derived from coenzyme A degradation, although its plasma concentrations …