Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose
to development of gastro-intestinal tumors. Central to the tumorigenic events in APC …

Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of
small-sized stem cell populations that continuously generate new progeny to replace lost …

LGR5 + stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt,
Notch and epidermal growth factor signals 1 . Here we find that the related RNF43 and …

FOXO (Forkhead box O) transcription factors are important regulators of cellular metabolism,
cell-cycle progression and cell death. FOXO activity is regulated by multiple post-…

Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the
key regulated step of the Wnt pathway. It is incompletely understood how the Axin1 complex …

Mammalian Wnt proteins are believed to act as short-range signals 1 , 2 , 3 , 4 , yet have not
been previously visualized in vivo. Self-renewal, proliferation and differentiation are …

Stable Foxp3 expression is required for the development of functional regulatory T (Treg)
cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be …

The p53 tumor suppressor protein has a major role in protecting the integrity of the genome.
In unstressed cells, p53 is maintained at low levels by the ubiquitin-proteasome pathway. A …

The glycolipoproteins of the Wnt family raise interesting trafficking issues, especially with
respect to spreading within tissues. Recently, the retromer complex has been suggested to …