The decision to enter mitosis is mediated by a network of proteins that regulate activation of
the cyclin B–Cdk1 complex. Within this network, several positive feedback loops can amplify …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these kinases …

Forkhead transcription factors of the FOXO family are important downstream targets of protein
kinase B (PKB)/Akt, a kinase shown to play a decisive role in cell proliferation and cell …

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent
cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates …

The spatial organization of chromosomes influences many nuclear processes including gene
expression. The cohesin complex shapes the 3D genome by looping together CTCF sites …

The FoxO forkhead transcription factors FoxO4 (AFX), FoxO3a (FKHR. L1), and FoxO1a (FKHR)
represent important physiological targets of phosphatidylinositol-3 kinase (PI3K)/protein …

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a
Forkhead factor that regulates longevity in Caenorhabditis elegans 1 , 2 , 3 . Here we show …

Reactive oxygen species are required for cell proliferation but can also induce apoptosis 1 .
In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also …

Cell death is regulated mainly through an evolutionarily conserved form of cell suicide termed
apoptosis [1]. Deregulation of apoptosis has been associated with cancer, autoimmune …

FOXO transcription factors have important roles in metabolism, cellular proliferation, stress
tolerance, and aging. FOXOs are negatively regulated by protein kinase B/c-Akt-mediated …