Mimotopes: realization of an unlikely concept
RH Meloen, WC Puijk… - Journal of molecular …, 2000 - Wiley Online Library
… Geysen HM, Barteling SJ, Meloen RH. 1984. Use of peptide synthesis to probe viral … Slootstra
JW, Puijk WC, Ligtvoet GJ, Kuperus D, Schaaper WMM, Meloen RH. 1997. Screening of a …
JW, Puijk WC, Ligtvoet GJ, Kuperus D, Schaaper WMM, Meloen RH. 1997. Screening of a …
Monitoring health by values of acute phase proteins
E Gruys, MJM Toussaint, TA Niewold, SJ Koopmans… - Acta histochemica, 2006 - Elsevier
A systemic acute phase reaction may develop during infection and inflammation, due to the
action of peripherally liberated proinflammatory cytokines. Hepatic metabolism changes, and …
action of peripherally liberated proinflammatory cytokines. Hepatic metabolism changes, and …
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.
HM Geysen, RH Meloen… - Proceedings of the …, 1984 - National Acad Sciences
A procedure is described for rapid concurrent synthesis on solid supports of hundreds of
peptides, of sufficient purity to react in an enzyme-linked immunosorbent assay. Interaction of …
peptides, of sufficient purity to react in an enzyme-linked immunosorbent assay. Interaction of …
Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces
P Timmerman, J Beld, WC Puijk, RH Meloen - ChemBioChem, 2005 - academia.edu
FSH-β peptide microarray: Peptides were synthesized on an amino-functionalized solid
support (polypropylene grafted with polyacryclic acid and treated with Boc-HMDA/DCC/HOBt …
support (polypropylene grafted with polyacryclic acid and treated with Boc-HMDA/DCC/HOBt …
Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie
LJ Van Keulen, BE Schreuder, RH Meloen… - Journal of Clinical …, 1996 - Am Soc Microbiol
The scrapie-associated form of the prion protein (PrPSc) accumulates in the brain and
lymphoid tissues of sheep with scrapie. In order to assess whether detecting PrPSc in lymphoid …
lymphoid tissues of sheep with scrapie. In order to assess whether detecting PrPSc in lymphoid …
Plant–derived vaccine protects target animals against a viral disease
K Dalsgaard, Å Uttenthal, TD Jones, F Xu… - Nature …, 1997 - nature.com
The successful expression of animal or human virus epitopes on the surface of plant viruses
has recently been demonstrated. These chimeric virus particles (CVPs) could represent a …
has recently been demonstrated. These chimeric virus particles (CVPs) could represent a …
Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees.
J Goudsmit, C Debouck, RH Meloen… - Proceedings of the …, 1988 - National Acad Sciences
Chimpanzees are susceptible to infection by divergent strains of human immunodeficiency
virus type 1 (HIV-1), none of which cause clinical or immunological abnormalities. …
virus type 1 (HIV-1), none of which cause clinical or immunological abnormalities. …
Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.
HM Geysen, SJ Barteling… - Proceedings of the …, 1985 - National Acad Sciences
Antisera were raised against the chemically synthesized peptide corresponding to each
epitope of three foot-and-mouth disease virus strains. Peptide synthesis was further used to …
epitope of three foot-and-mouth disease virus strains. Peptide synthesis was further used to …
Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.
WM Kast, L Roux, J Curren, HJ Blom… - Proceedings of the …, 1991 - National Acad Sciences
The only peptide of Sendai virus that is recognized by cytotoxic T lymphocytes (CTL) in B6
mice was found with (i) the use of recombinant vaccinia virus constructs containing separate …
mice was found with (i) the use of recombinant vaccinia virus constructs containing separate …
Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS™ technology
P Timmerman, WC Puijk… - Journal of Molecular …, 2007 - Wiley Online Library
This paper describes immunization studies with CLIPS‐constrained peptides covering only
the major part (β3‐loop) of a structurally complex antigenic site on human Follicle Stimulating …
the major part (β3‐loop) of a structurally complex antigenic site on human Follicle Stimulating …