THE PAST TWO DECADES have brought remarkable progress in our understanding of the
molecular basis of hemophilia A. This disease, which has already been documented as a …

The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes
acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two …

Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Background Infections due to antibiotic-resistant bacteria are threatening modern health
care. However, estimating their incidence, complications, and attributable mortality is …

The ability to differentiate stimuli predicting positive or negative outcomes is critical for
survival, and perturbations of emotional processing underlie many psychiatric disease states. …

Abnormal coagulation factor V may underlie the thrombotic events associated with resistance
to activated protein C (APC). We analysed 27 consecutive patients with documented …

This paper estimates the dynamic effects of changes in taxes in the United States. We
distinguish between changes in personal and corporate income taxes and develop a new …

Background: Diagnosis of the antiphospholipid syndrome (APS) is difficult as a result of limited
specificity of existing assays for detecting clinically relevant antiphospholipid antibodies. …

The acidic region of the Factor VIII light chain was studied with regard to structural requirements
for the formation of a functional von Willebrand factor (vWF)-binding site. Factor VIII …

Based on rich novel survey data on almost 5,000 working age adults, we document that
35.2 percent of the workforce worked entirely from home in May 2020, up from 8.2 percent in …