Health implications of exposure to environmental nitrogenous compounds
TT Mensinga, GJA Speijers, J Meulenbelt - Toxicological reviews, 2003 - Springer
All living systems need nitrogen for the production of complex organic molecules, such as
proteins, nucleic acids, vitamins, hormones and enzymes. Due to the intense use of synthetic …
proteins, nucleic acids, vitamins, hormones and enzymes. Due to the intense use of synthetic …
THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†
B Ploeger, T Mensinga, A Sips, W Seinen… - Drug metabolism …, 2001 - Taylor & Francis
Glycyrrhizic acid is widely applied as a sweetener in food products and chewing tobacco. In
addition, it is of clinical interest for possible treatment of chronic hepatitis C. In some highly …
addition, it is of clinical interest for possible treatment of chronic hepatitis C. In some highly …
[HTML][HTML] Pharmacokinetics and toxicity of tacrolimus early after heart and lung transplantation
MA Sikma, EM Van Maarseveen… - American Journal of …, 2015 - Elsevier
Annually, about 8000 heart and lung transplantations are successfully performed worldwide.
However, morbidity and mortality still pose a major concern. Renal failure in heart and lung …
However, morbidity and mortality still pose a major concern. Renal failure in heart and lung …
The oral bioavailability of nitrate from nitrate-rich vegetables in humans
AG van Velzen, AJAM Sips, RC Schothorst… - Toxicology letters, 2008 - Elsevier
High dietary nitrate intake may pose a risk to human health. Since up to 80–85% of dietary
nitrate intake comes from vegetables, the aim of this study was to determine the absolute …
nitrate intake comes from vegetables, the aim of this study was to determine the absolute …
Potato glycoalkaloids and adverse effects in humans: an ascending dose study
TT Mensinga, AJAM Sips, CJM Rompelberg… - Regulatory toxicology …, 2005 - Elsevier
Glycoalkaloids in potatoes may induce gastro-intestinal and systemic effects, by cell membrane
disruption and acetylcholinesterase inhibition, respectively. The present single dose …
disruption and acetylcholinesterase inhibition, respectively. The present single dose …
Extracorporeal membrane oxygenation in the treatment of poisoned patients
DW De Lange, MA Sikma, J Meulenbelt - Clinical Toxicology, 2013 - Taylor & Francis
Context. Although extracorporeal membrane oxygenation (ECMO) was used in many
patients following its introduction in 1972, most hospitals had abandoned this experimental …
patients following its introduction in 1972, most hospitals had abandoned this experimental …
Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC)
CC Hunault, TT Mensinga, KBE Böcker… - …, 2009 - Springer
Rationale Δ 9 -Tetrahydrocannabinol (THC) is the main active constituent of cannabis. In
recent years, the average THC content of some cannabis cigarettes has increased up to …
recent years, the average THC content of some cannabis cigarettes has increased up to …
Phase I clinical trial with a hexavalent PorA containing meningococcal outer membrane vesicle vaccine
C Peeters, HC Rümke, LC Sundermann… - Vaccine, 1996 - Elsevier
A meningococcal outer membrane vesicle (OMV) vaccine was prepared from two production
strains designed to express three serosubtype-specific class 1 outer membrane proteins or …
strains designed to express three serosubtype-specific class 1 outer membrane proteins or …
[PDF][PDF] Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol
SJ Rietjens, DW De Lange, J Meulenbelt - Neth J Med, 2014 - njmonline.nl
Toxicity of EG is related to the production of toxic metabolites by the hepatic enzyme alcohol
dehydrogenase (ADH). EG is oxidised to glycolaldehyde by ADH, and subsequently …
dehydrogenase (ADH). EG is oxidised to glycolaldehyde by ADH, and subsequently …
Bioavailability of sodium nitrite from an aqueous solution in healthy adults
CC Hunault, AG van Velzen, AJAM Sips… - Toxicology letters, 2009 - Elsevier
Nitrate intake in humans is high through intake of vegetables such as beets, lettuce, and
spinach. Nitrate itself is a compound of low toxicity but its metabolite, nitrite, formed by bacteria …
spinach. Nitrate itself is a compound of low toxicity but its metabolite, nitrite, formed by bacteria …