Simple Summary The value of animal research has been increasingly debated, owing to
high failure rates in drug development. A potential contributor to this situation is the lack of …

Background and Objectives Artificial intelligence (AI) is widely positioned to become a key
element of intelligent technologies used in the long-term care (LTC) for older adults. The …

Highlights • Study of impeding factors leading to system failure in drug development. •
Overview of solution directions to repair current drug development system. • Importance of safe, …

RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring
hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important …

The most pressing environmental problems of post-mining base metals production are solid
waste production, gaseous emissions, and a high energy use. Most of the present solutions …

Objective The objective was to identify barriers and facilitators to the implementation of
artificial intelligence (AI) applications in clinical radiology in The Netherlands. Materials and …

User involvement is assumed to be beneficial to innovation processes. Intermediary user
organisations contribute to articulating societal demands for innovations. However, the learning …

Postharvest losses along food supply chains have far reaching consequences for the
environment and affect the social and economic conditions of food supply chain participants, …

The immunogenicity of biopharmaceuticals used in clinical practice remains an unsolved
challenge in drug development. Non-human primates (NHPs) are often the only relevant …

New technologies must be accompanied by institutional change. Innovative actors therefore
need to do institutional work or take a role as an institutional entrepreneur in order to shape …