The UDP glucuronosyltransferase gene super family: suggested nomenclature based on evolutionary divergence
B Burchell, DW Nebert, DR Nelson, KW Bock… - DNA and cell …, 1991 - liebertpub.com
A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based
on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species …
on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species …
Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N, O-sulfonation in chemical carcinogenesis of aromatic …
GJ Mulder, JH Meerman - Environmental health perspectives, 1983 - ehp.niehs.nih.gov
Aromatic amines can be metabolized by N-acetylation and N-hydroxylation to hydroxamic
acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide …
acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide …
Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance
D Burg, GJ Mulder - Drug metabolism reviews, 2002 - Taylor & Francis
Alterations in levels of glutathione (GSH) and glutathione-dependent enzymes have been
implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, …
implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, …
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
M Cavazzana-Calvo, E Payen, O Negre, G Wang… - Nature, 2010 - nature.com
The β-haemoglobinopathies are the most prevalent inherited disorders worldwide. Gene
therapy of β-thalassaemia is particularly challenging given the requirement for massive …
therapy of β-thalassaemia is particularly challenging given the requirement for massive …
Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain
M Kruidering, B Van De Water, E De Heer… - … of Pharmacology and …, 1997 - ASPET
Cisplatin-induced nephrotoxicity was studied in porcine proximal tubular cells, focusing on
the relationship between mitochondrial damage, reactive oxygen species (ROS) and cell …
the relationship between mitochondrial damage, reactive oxygen species (ROS) and cell …
Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: a randomized clinical trial
G Raghu, B Van Den Blink, MJ Hamblin, AW Brown… - Jama, 2018 - jamanetwork.com
Importance Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with
poor prognosis. Approved therapies do not halt disease progression. Objective To determine …
poor prognosis. Approved therapies do not halt disease progression. Objective To determine …
Sulfation
GJ Mulder, WB Jakoby - Conjugation reactions in drug …, 1990 - taylorfrancis.com
Sulfation was discovered by Baumann around 1875 when he isolated phenyl sulfate from
the urine of a patient who had been treated with phenol. Althoughsulfation was subsequently …
the urine of a patient who had been treated with phenol. Althoughsulfation was subsequently …
[BOEK][B] Conjugation reactions in drug metabolism: an integrated approach
GJ Mulder - 1990 - books.google.com
This text investigates the molecular biology of conjugation, and the subsequent activity of
the transfered genes" in vivo". Conjugation may be very important when considering …
the transfered genes" in vivo". Conjugation may be very important when considering …
Pharmacokinetic and pharmacodynamic evaluation of liposomal amikacin for inhalation in cystic fibrosis patients with chronic pseudomonal infection
OO Okusanya, SM Bhavnani, J Hammel… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The pharmacokinetics and pharmacodynamics of a novel liposomal amikacin for inhalation
were evaluated in cystic fibrosis patients with chronic pseudomonas infection. Twenty-four …
were evaluated in cystic fibrosis patients with chronic pseudomonas infection. Twenty-four …
The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and γ-glutamyl domains
AEP Adang, J Brussee, A van der Gen… - Biochemical …, 1990 - portlandpress.com
The GSH-binding site of glutathione S-transferase (GST) isoenzymes was studied by
investigating their substrate-specificity for three series of GSH analogues; further, a model of the …
investigating their substrate-specificity for three series of GSH analogues; further, a model of the …
