… Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, Mummery CL . Prediction of
drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem …

The potential usefulness of human embryonic stem cells for therapy derives from their ability
to form any cell in the body. This potential has been used to justify intensive research …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic …

Background— Chronic heart failure is characterized by left ventricular remodeling and
reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here …

Deletion of the transforming growth factor β1 (TGF‐β1) gene in mice has previously suggested
that it regulates both hematopoiesis and angiogenesis. To define the function of TGF‐β …

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted
lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generates …

Defined growth conditions are essential for many applications of human embryonic stem
cells (hESC). Most defined media are presently used in combination with Matrigel, a partially …

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction…

NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-5
locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …

Recent withdrawals of prescription drugs from clinical use because of unexpected side
effects on the heart have highlighted the need for more reliable cardiac safety pharmacology …