Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
… Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, Mummery CL . Prediction of
drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem …
drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem …
Stem-cell-based therapy and lessons from the heart
R Passier, LW van Laake, CL Mummery - Nature, 2008 - nature.com
The potential usefulness of human embryonic stem cells for therapy derives from their ability
to form any cell in the body. This potential has been used to justify intensive research …
to form any cell in the body. This potential has been used to justify intensive research …
Induced pluripotent stem cells: the new patient?
Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic …
chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic …
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure
Background— Chronic heart failure is characterized by left ventricular remodeling and
reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here …
reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here …
[HTML][HTML] Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice
J Larsson, MJ Goumans, LJ Sjöstrand… - The EMBO …, 2001 - embopress.org
Deletion of the transforming growth factor β1 (TGF‐β1) gene in mice has previously suggested
that it regulates both hematopoiesis and angiogenesis. To define the function of TGF‐β …
that it regulates both hematopoiesis and angiogenesis. To define the function of TGF‐β …
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
LA Van Meeteren, P Ruurs, C Stortelers… - … and cellular biology, 2006 - Am Soc Microbiol
Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted
lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generates …
lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generates …
Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via αVβ5 integrin
SR Braam, L Zeinstra, S Litjens… - Stem …, 2008 - academic.oup.com
Defined growth conditions are essential for many applications of human embryonic stem
cells (hESC). Most defined media are presently used in combination with Matrigel, a partially …
cells (hESC). Most defined media are presently used in combination with Matrigel, a partially …
[HTML][HTML] Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction…
immature, but this is improved by incorporation into engineered tissues or forced contraction…
NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes
DA Elliott, SR Braam, K Koutsis, ES Ng, R Jenny… - Nature …, 2011 - nature.com
NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-5
locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …
locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …
[HTML][HTML] Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
SR Braam, L Tertoolen, A van de Stolpe, T Meyer… - Stem cell …, 2010 - Elsevier
Recent withdrawals of prescription drugs from clinical use because of unexpected side
effects on the heart have highlighted the need for more reliable cardiac safety pharmacology …
effects on the heart have highlighted the need for more reliable cardiac safety pharmacology …