The physician treating children with inflammatory bowel disease is confronted with a number
of specific problems, one of them being the lack of randomized, controlled drug trials in …

The gastrointestinal tract allows the residence of an almost enumerable number of bacteria.
To maintain homeostasis, the mucosal immune system must remain tolerant to the …

The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell
polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both …

Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …

Single murine and human intestinal stem cells can be expanded in culture over long time
periods as genetically and phenotypically stable epithelial organoids. Increased cAMP levels …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have shown …

We recently established conditions allowing for long-term expansion of epithelial organoids
from intestine, recapitulating essential features of the in vivo tissue architecture. Here we …

The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life
is associated with various age-related diseases, including cancer 1 , 2 . Extreme variation in …

Identifying subjects with cystic fibrosis (CF) who may benefit from cystic fibrosis transmembrane
conductance regulator (CFTR)–modulating drugs is time-consuming, costly, and …

CD1d-restricted T cells are implicated as key players in host defense against various
microbial infections. However, the mechanisms involved and the role they play, if any, at the …