Materials and Methods Cell Cultures The bronchial epithelial cell line BEAS-2B (16) was
obtained from Dr. 1. F. Lechner (National Institutes of Health, Bethesda, MD). The BEAS-2B cell …

… Folkerts G, Nijkamp FP. Virus-induced airway hyperresponsiveness: role of inflam- …

This review describes production and effects of reactive oxygen species (ROS) on airway
function. ROS are important in many physiological processes but can also have detrimental …

Wheezing is a common complication of respiratory infections (Table 1). In infancy, infections
with respiratory viruses, particularly respiratory syncytial virus (RSV) and parainfluenza virus …

The free radical nitric oxide (NO) is an important mediator of many biological processes.
Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function …

We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived
from the breakdown of extracellular matrix (ECM), which shares sequence and structural …

Immunoglobulin (Ig)-free light chains IgLC are present in serum and their production is
augmented under pathological conditions such as multiple sclerosis, rheumatoid arthritis and …

Allergic asthma is thought to be regulated by Th2 cells, and inhibiting this reponse is a
promising mode of intervention. Many studies have focused on differentiation of Th cells to the …

… Hessel EM, Van Oosterhout AJ, Van Ark I, Van Esch B, Hofman G, Van Loveren H, Savelkoul
HF, Nijkamp FP: Development of airway hyperresponsiveness is dependent on interferon-γ …

Peroxynitrite (ONOO − ) the highly reactive coupling product of nitric oxide and superoxide,
has been implicated in the pathogenesis of an increasing number of (inflammatory) diseases. …