A significant increase in life expectancy in successive birth cohorts of people with cystic
fibrosis (CF) is a result of more effective treatment for the disease. It is also now widely …

In this review we summarized literature data on the mechanisms of human placental drug
transport studied in the isolated perfused placental cotyledon, placental membrane vesicles or …

We particularly focus on the importance of patient-oriented research collaborations, and
how such a collaboration helped to develop a personalized medicine approach for CFTR …

In the Netherlands, special guidelines and safety precautions were introduced about 10 y ago
for preparation and administration of antineoplastic agents. However, little is known about …

The potency of indole-3-carbinol (I3C) to form condensation products under acidic aqueous
conditions was studied. After identifying a known dimer, 3,3′-diindolylmethane (DIM), we …

Research on epithelial cell lines and primary epithelium is required to dissect the mechanisms
underlying the structural abnormalities in airway epithelium observed for respiratory …

The molecular basis of airway remodeling and loss of epithelial integrity in asthma is still
undefined. We aimed to establish if exposure of human bronchial epithelium (16HBE cells) to …

To characterize the changes in the extracellular matrix in smoking-related pulmonary
emphysema, we undertook immunohistochemical studies in lung tissues from controls (n= 7), from …

Chronic obstructive pulmonary disease (COPD) is a life-threatening disease with an ongoing
increase in mortality worldwide. COPD is characterized by airway inflammation, irreversible …

Mild hyperhomocysteinemia is frequently observed in mothers who gave birth to a child with
a neural tube defect (NTD). In a previous study we showed L‐homocysteine was …