Invasive pancreatic ductal adenocarcinoma is an almost uniformly fatal disease. Several
distinct noninvasive precursor lesions can give rise to invasive adenocarcinoma of the pancreas…

Gastric cancer is the second most common cause of cancer-related deaths in the world, the
epidemiology of which has changed within last decades. A trend of steady decline in gastric …

The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming
and the relevant importance of some of these molecules is too often unclear. This review …

Background Familial adenomatous polyposis is an autosomal dominant disorder characterized
by the formation of hundreds of colorectal adenomas and eventual colorectal cancer. …

Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins
and a second type, unable to transport hydrophobic anticancer drugs. The latter is …

Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been
the subject of numerous morphologic, clinical, and genetic studies; however, a standard …

Background Turcot's syndrome is characterized clinically by the concurrence of a primary
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …

The Peutz–Jeghers syndrome is an autosomal dominant hereditary disease characterized
by hamartomatous polyps of the gastrointestinal tract and by mucocutaneous melanin …

Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established,
data on the spectrum of tumors associated with the disease and the influence of germ-line …

Little is known about the signaling mechanisms that determine the highly regular patterning
of the intestinal epithelium into crypts and villi. With the use of mouse models, we show that …