Prior to the genome-wide association era, candidate gene studies were a major approach in
schizophrenia genetics. In this invited review, we consider the current status of 25 historical …

Although family and twin studies show that there is a genetic component to migraine, no
genes predisposing to common forms of the disorder have been identified. The most …

Objective: Several studies have suggested an increased frequency of variants in the gene
encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Genes for familial hemiplegic migraine (FHM) and episodic ataxia type-2 (EA-2) have been
mapped to chromosome 19p13. We characterized a brain-specific P/Q-type Ca 2+ channel …

Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …